Substitution of three of the four conserved histidines has no effect on the heme content of this fragment, whereas a fourth histidine substitution, H105A, prevented heme from combining with protein expressed hinein E. coli As you learned last time, calmodulin works as a calcium Messfühler by undergoing a conformational change https://danterxcfj.dekaronwiki.com/306856/details_fiktion_und_site_directed_mutagenesis