Abnormal activation of the Wnt/β-catenin pathway encourages CSC development and therefore results in the deterioration and metastasis of most cancers [129]. For instance, abnormal activation of Wnt signaling disrupted the traditional advancement and differentiation of colonic crypt stem cells, resulting in a colorectal CSC phenotype by upregulating expression of target https://rylanoizqi.angelinsblog.com/23672921/everything-about-pha-665752