It is actually interesting to note that when the DCM-causing mutation K36Q in cTnI was introduced within the existence of Ca2+, the simulation confirmed that Ser 22 and 23 not interacted closely with cTnC, in accord with our speculation the Ca2+-cTnC-cTnI N terminus interaction is exclusive and is particularly destabilized https://carlw100itd2.governor-wiki.com/user