We hypothesized that HHcy induces arterial hypertension from the accumulation of ECM elements among endothelial and arterial smooth muscle mass cells, which leads to subsequent endothelium-myocyte (E-M) uncoupling in response to MMP activation. This critique write-up is the initial to debate gypsogenin and its spinoff from the medicinal chemistry perspective. https://feruloylputrescine54321.blogofchange.com/28670463/cathepsin-s-protein-an-overview