Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts in the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, wh... https://virgilu593qzj8.wikiusnews.com/user