Renal impairment Pregabalin is eradicated within the systemic circulation mainly by renal excretion as unchanged drug. As pregabalin clearance is directly proportional to creatinine clearance (see segment 5. In prenatal/postnatal toxicity scientific tests, pregabalin induced offspring developmental toxicity in rats at exposures > two periods the utmost suggested human exposure. https://peterl765zjq5.wssblogs.com/profile